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Ghosh, Tarun K.
- Functionality Search in Hypothetical Proteins of Halobacterium Salinarum
Abstract Views :175 |
PDF Views:1
Authors
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1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur- 440020, IN
2 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, IN
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur- 440020, IN
2 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, IN
Source
Fuzzy Systems, Vol 3, No 5 (2011), Pagination: 164-187Abstract
The Halobacterium salinarum are extremely halophilic archaeon. The complete genome sequence of Halobacterium salinarum was deciphered, which revealed the presence of various gene for hypothetical proteins whose function are not yet understood. We analyzed complete genome of Halobacterium salinarum for hypothetical proteins from which 524 uncharacterized proteins showed conserved domains for biologically active components. Our attempt is to predict the function of these hypothetical proteins by the application of computational methods and Bioinformatics. The probable function prediction of the hypothetical protein was done by using Bioinformatics web tools like CDD-BLAST, INTERPROSCAN, PFAM and COGs by searching sequence databases for the presence of orthologous enzymatic conserved domains in the hypothetical sequences. These study revealed presences of enzymatic functional domain in Halobacterium salinarum; their roles are yet to be discovered. These deciphered enzymatic data for hypothetical proteins can be used for the understanding of functional, structural, evolutionary and metabolic development of Halobacterium spp. and its life cycle along with their role in host evolution and adaptation.Keywords
Bioinformatics Web Tools, Conserved Domains, Uncharacterized Proteins, Life Cycle, Host Evolution.- Insilico Function Prediction for Hypothetical Proteins in Vibrio Parahaemolyticus Chromosome II
Abstract Views :219 |
PDF Views:2
Authors
Affiliations
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nagpur-440020, IN
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nagpur-440020, IN
Source
Data Mining and Knowledge Engineering, Vol 3, No 7 (2011), Pagination: 404-432Abstract
The Vibrio parahaemolyticus is the potential food poisoning agent. The complete genome sequencing of Vibrio parahaemolyticus has been done which deciphered the presence of various gene for hypothetical proteins whose function is not yet understood. We analyzed complete genome of Vibrio parahaemolyticus for hypothetical proteins from which 458 were functionally classified into their respective protein families. Our attempt is to predict the functions of these hypothetical proteins by the application of computational methods and Bioinformatics. The probable function prediction of the hypothetical protein was done by using Bioinformatics web tools like CDD-BLAST, INTERPROSCAN, PFAM and COGs by searching sequence databases for the presence of orthologous enzymatic conserved domains in the hypothetical sequences. These study revealed presences of enzymatic functional domain in 458 uncharacterized proteins; their roles are yet to be discovered in Vibrio parahaemolyticus. These deciphered enzymatic data for hypothetical proteins can be used for the understanding of functional, structural, evolutionary and metabolic development of Vibrio parahaemolyticus and its life cycle along with their role in host evolution and pathogenicity.Keywords
Bioinformatics Web Tools, Conserved Domains, Uncharacterized Proteins, Life Cycle, Host Evolution.- Computational Approach for Structure and Functionality Search for Hypothetical Proteins in Mycobacterium Leprae
Abstract Views :192 |
PDF Views:4
Authors
Affiliations
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, IN
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, IN
Source
Data Mining and Knowledge Engineering, Vol 3, No 5 (2011), Pagination: 281-296Abstract
Mycobacterium leprae Br4923 the causative agent of leprosy is one of the most puzzling and complex microorganism due to its gene decaying property and presence of large number of pseudogenes. The proper treatment of leprosy is not yet possible due to its drug resistance mechanism and uncultivable nature on culture media. The present work deals with the prediction of structure and function of hypothetical proteins in M. Leprae by the use of computational methods and bioinformatics. The prediction of orthologous sequence in biological sequence databases, assist in classification of 180 hypothetical protein sequences in their respective protein family by the use of web tools (CDD-BLAST, INTERPROSCAN, PFAM and COGs). The 3-D structures of the 160 functionally resolved hypothetical proteins were constructed using PS2 server (Protein structure prediction server). The generated data can prove useful in the prediction of evolutionary relationship of Mycobacterium leprae with those of other related Mycobacterium species. It may also assist in the designing of novel drug to treat leprosy.Keywords
Gene Decay, Pseudogenes, Uncultivable, Web Tools, Evolutionary Relationship.- Study of Hypothetical Proteins in Salmonella Phages and Predicting their Structural and Functional Relationship
Abstract Views :166 |
PDF Views:4
Authors
Affiliations
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, Maharashtra, IN
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, Maharashtra, IN
Source
Biometrics and Bioinformatics, Vol 3, No 2 (2011), Pagination: 70-73Abstract
The present study of hypothetical proteins in Salmonella phages was carried out for predicting their structure and function relationship. Such applications for bacteriophages are not yet reported and there is a great need to understand the mechanism by which they impart the virulence, resistance and other novel characteristics to the host they infect. We are reporting the structure and functions of hypothetical proteins in Salmonella phages for understanding their role in Salmonella spp. The complete analysis of hypothetical proteins from 8 different Salmonella phage genomes were carried out by the using bioinformatics web tools like CDD-BLAST, INTERPROSCAN, PFAM and COGs by searching orthologous enzymatic conserved domains in the hypothetical sequences. While tertiary structures were constructed using PS2 Server (Protein Structure Prediction server). These studies revealed presences of enzymatic functional domain in 110 uncharacterized proteins and 3-D protein structure were predicted for 29 hypothetical proteins. These deciphered enzymatic data for hypothetical proteins can be used for the understanding of functional, structural, and evolutionary development of Salmonella phages and its life cycle along with their role in host evolution and pathogenicity.Keywords
Virulence, Bioinformatics Web Tools, Conserved Domains, Uncharacterized Proteins, Life Cycle and Pathogenicity.- Computational Characterizations for Structure and Function of Unclassified Proteins in Ictalurus punctatus
Abstract Views :188 |
PDF Views:2
Authors
Affiliations
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, IN
1 Applied Aquatic Ecosystem Division, National Environmental Engineering Research Institute, IN